Spatial Conformation of Pancreatic Cancer Is Associated with Disease Recurrence after Curative-Intent Total Neoadjuvant Therapy Pancreatic ductal adenocarcinoma (PDAC) frequently recurs after total neoadjuvant therapy (TNT) and curative-intent resection. Traditional histopathologic response assessments demonstrate that major pathologic response (<5-10% viable residual cancer) is associated with favorable outcomes. However, most TNT cases achieve only a minor response. We investigated whether the spatial organization of residual PDAC encodes clinically meaningful biology beyond residual tumor burden. In a… bioRxiv Cancer Biology November 7, 2025 Original source
Synthesis and Preclinical Development of a Novel 68Ga/89Zr-Labelled α{nu}β6-Integrin Targeting Trimer The v{beta}6 integrin has emerged as a valuable target for theranostic applications in nuclear medicine with high applicability across a variety of cancers, including head-and-neck, lung, breast, and pancreatic carcinomas. [Ga]Ga-Trivehexin is a prominent example of a diagnostic tracer targeting this integrin. In this work, we aimed to expand on this concept by developing FSC(PEG4-v{beta}6), a novel tracer that retains… bioRxiv Cancer Biology November 7, 2025 Original source
A Minimal Plasma Proteome-Based Biomarker Panel for Accurate Prostate Cancer Diagnosis Early and accurate diagnosis of prostate cancer (PRC) remains a major clinical challenge, particularly with existing biomarker panels relying on invasive sampling or large biomarker panels with limited interpretability. Here, we present a machine learning framework for discovering compact and biologically grounded plasma protein signatures for PRC classification using publicly available pan-cancer proteomic data. We coupled a genetic algorithm-based protein… bioRxiv Cancer Biology November 7, 2025 Original source
NOVEL SMALL-MOLECULE INHIBITORS OF THE PROTEIN KINASE DYRK: POTENTIAL THERAPEUTIC CANDIDATES IN CANCER Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) is crucial for normal brain development and its disruption has been linked to various cancers. DYRK1A drives glioblastoma (GBM) progression via stabilization of epidermal growth factor receptor (EGFR). Here we describe two, selective, benzothiazole-derived DYRK inhibitors, FC-2 and FC-3, obtained by structure-activity optimization of a natural product lead. Both compounds inhibit DYRK1A with nanomolar potency… bioRxiv Cancer Biology November 7, 2025 Original source
Integrated Proteomic and Epigenomic Analysis Reveals IGF2 as a Vulnerability in PRC2-Deficient Malignant Peripheral Nerve Sheath Tumors Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with limited therapeutic options. Loss of the Polycomb repressive complex 2 (PRC2), via inactivating mutations in SUZ12 or EED, occurs frequently in MPNSTs and is associated with poor prognosis. However, the downstream chromatin and signaling consequences of these mutations remain incompletely understood. Here, we show that PRC2 deficiency in MPNST cells… bioRxiv Cancer Biology November 7, 2025 Original source
Reports of new illnesses slows; CDC continues to investigate the <em>Listeria </em>outbreak linked to deli meats Reports of new illnesses slows; CDC continues to investigate the Listeria outbreak linked to deli meats CDC Cancer News November 7, 2025 Original source
CDC Statement on Marburg Cases in Rwanda CDC is aware of 26 individuals with Marburg virus disease, as confirmed by the Republic of Rwanda Ministry of Health. CDC Cancer News November 7, 2025 Original source
Potential public health risk among individuals ordering counterfeit prescription medications from online pharmacies Potential public health risk among individuals ordering counterfeit prescription medications from online pharmacies CDC Cancer News November 7, 2025 Original source
CDC Confirms New Human Cases of H5 Bird Flu in California CDC Confirms New Human Cases of H5 Bird Flu in California CDC Cancer News November 7, 2025 Original source
CDC Confirms 3rd Human Case of H5 Bird Flu in California The Centers for Disease Control and Prevention (CDC) has confirmed a third human case of H5 bird flu in California. CDC Cancer News November 7, 2025 Original source
Youth Tobacco Product Use at a 25-Year Low, Yet Disparities Persist Current tobacco product use among U.S. middle and high school students has dropped to the lowest recorded level in 25 years. CDC Cancer News November 7, 2025 Original source
Severe E. coli outbreak in Mountain West states linked to McDonald's Quarter Pounders; McDonald's removes suspect ingredients temporarily A CDC Food Safety Alert regarding an outbreak of E. coli infections linked to McDonald's Quarter Pounders has been posted at https://www.cdc.gov/ecoli/outbreaks/e-coli-O157.html CDC Cancer News November 7, 2025 Original source
CDC Recommends Lowering the Age for Pneumococcal Vaccination from 65 to 50 Years Old Today, CDC Director Mandy Cohen endorsed the CDC Advisory Committee on Immunization Practices' (ACIP) recommendation for lowering the age for pneumococcal vaccination from 65 to 50 years old. CDC Cancer News November 7, 2025 Original source
CDC Recommends Second Dose of 2024-2025 COVID-19 Vaccine for People 65 Years and Older and for People Who are Moderately or Severely Immunocompromised Today, CDC Director Mandy Cohen endorsed the CDC Advisory Committee on Immunization Practices’ (ACIP) recommendation for people 65 years and older and those who are moderately or severely immunocompromised to receive a second dose of 2024-2025 COVID-19 vaccine six months after their first dose. CDC Cancer News November 7, 2025 Original source
More cases reported in E. coli outbreak linked to McDonald’s Quarter Pounders; Taylor Farms recalls onions sent to restaurants An update to CDC's Food Safety Alert regarding an outbreak of <em>E. coli</em> infections linked to McDonald's Quarter Pounders has been posted CDC Cancer News November 7, 2025 Original source
Lassa Fever Suspected in Death of U.S. Traveler Returning from West Africa The CDC and the Iowa Department of Health are investigating a suspected case of Lassa fever, which was diagnosed today in an Iowa resident who returned to the United States from West Africa early this month. CDC Cancer News November 7, 2025 Original source
Onions served at McDonald's are likely source of E. coli outbreak An update to CDC's Food Safety Alert regarding an outbreak of <em>E. coli</em> infections linked to onions served at McDonald's CDC Cancer News November 7, 2025 Original source
Transcript for MMWR Telebriefing: Evidence of Recent H5 Bird Flu Infections among Dairy Workers and CDC Guidance Updates Transcript for MMWR Telebriefing: Evidence of Recent H5 Bird Flu Infections among Dairy Workers and CDC Guidance Updates CDC Cancer News November 7, 2025 Original source
2023 CDC data suggest the STI epidemic may be slowing The number of sexually transmitted infections (STIs) remains high in the United States, however the latest data from CDC show signs the epidemic could be slowing CDC Cancer News November 7, 2025 Original source
Measles cases surge worldwide, infecting 10.3 million people in 2023 Measles cases surge worldwide, infecting 10.3 million people in 2023 CDC Cancer News November 7, 2025 Original source