Pancreatic ductal adenocarcinoma (PDAC) frequently recurs after total neoadjuvant therapy (TNT) and curative-intent resection. Traditional histopathologic response assessments demonstrate that major pathologic response (<5-10% viable residual cancer) is associated with favorable outcomes. However, most TNT cases achieve only a minor response. We investigated whether the spatial organization of residual PDAC encodes clinically meaningful biology beyond residual tumor burden. In a…
Spatial Conformation of Pancreatic Cancer Is Associated with Disease Recurrence after Curative-Intent Total Neoadjuvant Therapy
bioRxiv Cancer Biology | | Cisneros, L. H., Toruner, M. D., siddiqui, Z., Maraone, A. V., Lin, M., Xiao, A., Thiels, C., Truty, M. J., George, B., Jazieh, K., McWilliams, R., Maley, C. C., Hartley, C., Elhalaby, R., Dizona, P., Shi, Q., Fernandez-Zapico, M. E., Carr, R. M.
Topics: pancreatic-cancer, blood-cancer, cervical-cancer