Improved survival and rising incidence: insights from the largest retrospective study on leptomeningeal metastases in patients with NSCLC

Leptomeningeal metastatic disease (LMD) is a relatively rare but devastating manifestation of non-small-cell lung cancer (NSCLC), historically associated with poor survival and limited benefit from systemic therapy.1 Data on patients with NSCLC and LMD remain scarce, as these patients are generally excluded from clinical trials.2 Therefore, the work of Zheng et al. represents a significant contribution by providing the largest…