Targeting the epigenome and immune evasion: a new chapter in PRMT5 inhibition

The landscape of oncology continues to evolve as novel therapeutic strategies aim to overcome resistance to standard of care therapies and target tumor vulnerabilities more precisely. Protein arginine methyltransferase 5 (PRMT5) is a critical epigenetic regulator that symmetrically dimethylates arginine (SDMA) residues on histones and other substrates. As a consequence, PRMT5 plays a central role in gene expression, splicing, and…