Unveiling the molecular and immunological drivers of antibody–drug conjugates in cancer treatment

<p>Nature Reviews Cancer, Published online: 02 October 2025; <a href="https://www.nature.com/articles/s41568-025-00869-w">doi:10.1038/s41568-025-00869-w</a></p>Antibody–drug conjugates are rapidly expanding both in the clinical treatment of cancer and in preclinical development. In this Review, Zippelius et al. highlight the molecular interactions and immune system effects of these sophisticated drugs that drive their efficacy and toxicity.