Decoding ferroptosis for cancer therapy

<p>Nature Reviews Cancer, Published online: 10 October 2025; <a href="https://www.nature.com/articles/s41568-025-00864-1">doi:10.1038/s41568-025-00864-1</a></p>Although ferroptosis, an iron-dependent form of regulated cell death, is emerging as a therapeutic vulnerability in cancer, clinical translation is hindered by context-dependent regulation, a lack of predictive biomarkers and challenges in clinical trial design. In this Review, Wahida and Conrad examine the biological basis of ferroptosis, including its immunogenic potential,…