Mechanisms, challenges and opportunities for FLASH radiotherapy in cancer

<p>Nature Reviews Cancer, Published online: 24 October 2025; <a href="https://www.nature.com/articles/s41568-025-00878-9">doi:10.1038/s41568-025-00878-9</a></p>FLASH radiotherapy demonstrates reduced complications in healthy tissues while effectively targeting tumours. In this Perspective, Vozenin et al. review the clinical implications, mechanistic basis and provide novel hypotheses for FLASH efficacy.