Primary tumor chromatin landscape governs metastatic organotropism

<p>Nature Cancer, Published online: 10 October 2025; <a href="https://www.nature.com/articles/s43018-025-01048-4">doi:10.1038/s43018-025-01048-4</a></p>Little is known about how mutations in genes encoding tumor suppressors influence metastatic site selection and whether sustained inactivation of such genes influences tumor maintenance at these sites. A new study shows that restoration of Smad4 expression in extant pancreatic metastases has anti-tumor effects in the liver but pro-tumor effects in the…