Epigenetic regulation of T cell exhaustion in cancer

<p>Nature Reviews Cancer, Published online: 27 October 2025; <a href="https://www.nature.com/articles/s41568-025-00883-y">doi:10.1038/s41568-025-00883-y</a></p>Transcriptional and epigenetic mechanisms governing T cell exhaustion substantially impact immunotherapy effectiveness. In this Review, Kang et al. outline epigenetic regulatory programmes that influence T cell differentiation fates, proposing strategies to enhance clinical outcomes and immunotherapy durability in cancer through improved understanding of T cell biology.