Background <p>Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a newly identified immunosuppressive regulator, but its mechanism of suppressing antitumor immunity remains ambiguous. This study aims to uncover the underlying mechanism by which PCSK9 promotes hepatocellular carcinoma (HCC) immune escape and to explore potential intervention strategies.</p> Methods <p>Co-culture assay assessed the cytotoxicity of CD8<sup>+</sup> T cells against PCSK9-knockout HCC cells. Hepa1-6,…
Blocking PCSK9 suppresses hepatocellular carcinoma immune escape by decreasing FLI1-mediated SPP1 and PD-L1 expression
Journal for ImmunoTherapy of Cancer | | Hu, C., Qin, M., Lai, W., Zhou, H., Yuan, C., Liu, Y., Dai, Y., Yang, M., Hu, M., Wang, X., Luo, M., Zhang, R., Li, G.
Topics: liver-cancer, cervical-cancer, immunotherapy, chemotherapy, research
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