Background <p>Heat shock protein 47 (HSP47) is crucial for protein quality control and tumor progression. While its role in cancer biology is well established, its impact on cancer immunity remains poorly understood. In this study, we aim to elucidate how HSP47 inhibition modulates immune evasion, with a specific focus on the CD155/T-cell immunoreceptor with Ig and ITIM domains (TIGIT) axis…
HSP47 inhibition-induced CD155 expression through TRAF2 deubiquitination promotes tumor immune evasion
Journal for ImmunoTherapy of Cancer | | Mou, H., Qu, H., Chen, S., Zhang, W., Chen, L., Wang, Z., Eloy, Y., Shao, Z., Zhou, H., Xue, Y., Sun, H., Wang, F., Chai, X., Zhang, J., Yao, M., Zhao, S., Lei, J., Jin, L., Lu, S., Li, B., Wang, Z., Ye, Z.
Topics: research
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