ER stress sparks nerve pain

<p>Nature Reviews Cancer, Published online: 28 November 2025; <a href="https://www.nature.com/articles/s41568-025-00896-7">doi:10.1038/s41568-025-00896-7</a></p>A common side effect of treatment with taxane-based chemotherapy is peripheral neuropathy. Now, Fonseca et al. uncover the endoplasmic reticulum (ER) stress response in leukocytes as the effective mediator of paclitaxel-induced peripheral nerve damage.