Multimodality therapy, including surgery, radiotherapy, and systemic therapy, has significantly improved overall survival for patients with brain metastases. However, treatment-related neurocognitive sequelae remain a major challenge in survivorship. Although advances in radiotherapy delivery techniques have reduced toxicity, the potential interaction with chemotherapy, targeted therapy, and immunotherapy, and the consequent effect on neurocognitive outcomes is poorly characterised. We conducted a systematic…
[Review] Neurocognitive outcomes in patients with brain metastases: a systematic review
The Lancet Oncology | | Tarek Bou Dargham, Sebastian F Winter, Kristen Batich, Karin Gehring, Michael W Parsons, Jorg Dietrich, Trey Mullikin, Zachary J Reitman, Scott R Floyd, John P Kirkpatrick, Paul W Sperduto, Jona Hattangadi-Gluth, Helen A Shih, Paul D Brown, Minesh Mehta, Erik P Sulman, Katherine B Peters, Eugene J Vaios
Topics: blood-cancer, brain-cancer, immunotherapy, targeted-therapy, chemotherapy, radiation, clinical-trials, research