Vorasidenib reduced tumour growth rate and improved seizure control compared with placebo, with no observed negative effects on HRQOL or neurocognition. Additional follow-up supported the robustness of progression-free survival and time to next intervention in patients with grade 2 IDH1/2-mutant diffuse glioma. These findings support the use of vorasidenib in patients with grade 2 IDH1/2-mutant gliomas who only had surgical…
[Articles] Vorasidenib in IDH1-mutant or IDH2-mutant low-grade glioma (INDIGO): secondary and exploratory endpoints from a randomised, double-blind, placebo-controlled, phase 3 trial
The Lancet Oncology | | Timothy F Cloughesy, Martin J van den Bent, Mehdi Touat, Deborah T Blumenthal, Katherine B Peters, Benjamin M Ellingson, Jennifer L Clarke, Joe Mendez, Shlomit Yust-Katz, Liam Welsh, Warren P Mason, Francois Ducray, Yoshie Umemura, Burt Nabors, Matthias Holdhoff, Andreas F Hottinger, Yoshiki Arakawa, Juan M Sepulveda, Wolfgang Wick, Riccardo Soffietti, James Perry, Pierre Giglio, Macarena de la Fuente, Elizabeth Maher, Andrew Bottomley, Adriana E Tron, Denise Yi, Dan Zhao, Shuchi S Pandya, Lori Steelman, Islam Hassan, Patrick Y Wen, Ingo K Mellinghoff, INDIGO trial investigators
Topics: brain-cancer, clinical-trials, research