MB-FUS plus temozolomide is a safe combinatorial therapeutic approach for individuals with high-grade glioma, with the potential to improve survival and enable non-invasive plasma biomarker-based disease surveillance (sono-liquid biopsy), warranting randomised controlled trials.
[Articles] Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial
The Lancet Oncology | | Graeme F Woodworth, Pavlos Anastasiadis, Ahmad Ozair, Jeremi Chabros, Chetan Bettegowda, Chixiang Chen, Jakob V E Gerstl, Christopher Douville, Rania A Mekary, Timothy R Smith, Ying Meng, Cynthia Hawkins, Christopher B Pople, Agessandro Abrahao, Maheleth Llinas, Chinthaka Heyn, Adomas Bunevicius, Ali R Rezai, Anna J S Ball, Kaitlyn Henry, Arjun Sahgal, Erickson Torio, Haoyu Ren, Haroon Ahmad, Harshit Arora, Howard Eisenberg, James Perry, Jeffrey S Carpenter, Kullervo Hynynen, Lily C Pham, Mary Beth Anketell, Mary Jane Lim-Fat, Zhiyuan Xu, Christopher P Cifarelli, Jason P Sheehan, Nathan J McDannold, Dheeraj Gandhi, Alexandra J Golby, Nir Lipsman
Topics: brain-cancer, targeted-therapy, clinical-trials, prevention, new-technology, research