In pMMR/MSS stage II–III rectal cancer, total neoadjuvant therapy followed by non-operative management allows organ preservation in some patients without compromising distant relapse-free survival, supporting non-operative management as a treatment option in clinical practice.
[Articles] Total neoadjuvant therapy followed by non-operative management or surgery in stage II–III rectal cancer (NO-CUT): a multicentre, single-arm, phase 2 trial
The Lancet Oncology | | Alessio Amatu, Giorgio Patelli, Maria Giulia Zampino, Francesca Bergamo, Stefania Mosconi, Federica Tosi, Davide Ciardiello, Sara Lonardi, Giorgia Negrini, Daniela Sibio, Marianna Alessandra Gerardi, Sara Galuppo, Francesco Romeo Filippone, Pietro Carnevali, Simona Borin, Pierluigi Pilati, Elia Poiasina, Erica Bonazzina, Lorenzo Gervaso, Enzo Mammano, Francesco Bracco, Luca Bergamaschi, Gaya Spolverato, Matteo Origi, Uberto Fumagalli Romario, Gianluca Mauri, Nicola Fazio, Edoardo Forti, Giuseppe De Roberto, Chiara Cristofori, Cesare Burti, Luigi Asmundo, Luigi Funicelli, Gaetano Ramondo, Pietro Andrea Bonaffini, Sara Mariano, Luca Lazzari, Silvia Ghezzi, Claudio Isella, Daniela Cantarella, Maria Costanza Aquilano, Luca Bottiglieri, Emanuela Bonoldi, Massimiliano Mutignani, Valter Torri, Enzo Medico, Alberto Bardelli, Silvia Marsoni, Angelo Vanzulli, Mauro Filippo Palazzi, Giovanni Carlo Ferrari, Katia Bencardino, Andrea Sartore-Bianchi, Salvatore Siena
Topics: colorectal-cancer, blood-cancer, clinical-trials, research