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MEF2D-expressing cancer precursors reprogram tissue-resident macrophages to support liver tumorigenesis

Nature Cancer | November 7, 2025 | Cheng Qian

<p>Nature Cancer, Published online: 23 October 2025; <a href="https://www.nature.com/articles/s43018-025-01059-1">doi:10.1038/s43018-025-01059-1</a></p>Qian and colleagues show that MEF2D+ cancer precursors reprogram liver-resident Kupffer cells to create a microenvironment supporting liver tumorigenesis.

Topics: liver-cancer

Read the full article at Nature Cancer