Microbiota and immune-related adverse events in cancer immunotherapy

<p>Nature Reviews Cancer, Published online: 16 April 2026; <a href="https://www.nature.com/articles/s41568-026-00921-3">doi:10.1038/s41568-026-00921-3</a></p>Immune-related adverse events (irAEs) complicate cancer immunotherapy, necessitating cancer treatment cessation and management of irAEs. In this Progress article, Schneider et al. highlight the role of the microbiome in driving irAE development and progression, particularly immune checkpoint inhibitor-associated colitis, through clinical and preclinical evidence, emphasizing immune and microbial interactions while discussing…