Background <p>Small cell lung cancer (SCLC) is a recalcitrant malignancy with limited responses to immunotherapy, largely due to its uniquely immunosuppressive tumor microenvironment (TME). However, the molecular mechanisms driving this phenotype remain incompletely understood.</p> Methods <p>We integrated single-cell RNA sequencing and Xenium in situ spatial transcriptomics to analyze the immune microenvironment of five SCLC and four non-small cell lung cancer…
Single-cell and spatial transcriptomics reveal that the CXCL12-CXCR4 axis drives the immune-desert phenotype in small cell lung cancer by recruiting immunosuppressive CXCR4+ neutrophils and S100A8+ monocytes
Journal for ImmunoTherapy of Cancer | | Zeng, P., Li, H.-F., Shu, W.-B., Zhang, J., Zhao, T.-C., Hu, J.-W., Wang, J.-F., Wang, C., Lu, Q.-Y., Yang, J.-H., An, Y.-L., Chen, R.
Topics: lung-cancer, skin-cancer, blood-cancer, cervical-cancer, immunotherapy, new-technology, research
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