<p>A 52-year-old man presented with sarcomatoid diffuse pleural mesothelioma that had relapsed at an isolated site after a complete response to dual-immune checkpoint inhibition (ICI). Targeted sequencing exhibited amplification of chromosome 9p24, encompassing JAK2, PD-L1, PD-L2, and PTPRD in the relapsed (post-ICI) tumor, compared with baseline (pre-ICI). On multiplex immunofluorescence, tumor-associated macrophages (TAMs) and CD8<sup>+</sup> cytotoxic T lymphocytes (CTLs) made…
Regional immunosuppression and associated systemic markers in focally relapsed sarcomatoid mesothelioma: case report
Journal for ImmunoTherapy of Cancer | | Ollila, H., Kulkarni, P., Kim, H., Ankola, P., Chintala, N. K., Thomas, C., Sauter, J. L., Offin, M., Adusumilli, P. S.
Topics: lung-cancer, blood-cancer, cervical-cancer, sarcoma, immunotherapy, chemotherapy, clinical-trials
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