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Comprehensive molecular characterization of cfDNA as predictive and monitoring biomarkers in advanced gastric cancer receiving immunotherapy

Journal for ImmunoTherapy of Cancer | April 15, 2026 | Fang, J., Yu, Y., Sun, Y., Ji, M., Jiang, Y., Chen, X., Yan, C., Jin, G.

Background <p>Advanced gastric cancer (aGC) exhibits substantial heterogeneity in response to combination immunotherapy. Circulating cell-free DNA (cfDNA) enables non-invasive profiling of tumor dynamics and may provide biomarkers for response prediction.</p> Methods <p>We enrolled 94 patients with aGC undergoing combination immunotherapy and assigned them to a discovery set (n=49) and an internal validation set (n=45). Plasma cfDNA was collected pre-treatment and…

Topics: skin-cancer, stomach-cancer, immunotherapy, targeted-therapy, new-technology, research

Read the full article at Journal for ImmunoTherapy of Cancer