vCATCH enables body-wide in vivo drug distribution mapping

<p>Nature Reviews Cancer, Published online: 15 April 2026; <a href="https://www.nature.com/articles/s41568-026-00931-1">doi:10.1038/s41568-026-00931-1</a></p>In this Tools of the Trade article, Zhengyuan Pang describes the development and use of volumetric clearing-assisted tissue click chemistry (vCATCH), a pipeline that enables mapping of covalent drug binding at cellular resolution across a mouse body.