Deep learning-driven recognition of panoramic tumor microenvironment features in H&E sections and its application

<p>The tumor microenvironment (TME), composed of tumor cells together with stromal cells, immune cells, vascular networks, and other components, constitutes a complex ecosystem that plays a decisive role in tumor initiation, progression, metastasis and therapeutic response. Traditional pathological diagnosis mainly relies on pathologists manually examining H&amp;E-stained tissue sections under the microscope, a method that not only suffers from substantial interobserver…