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Targeting the neuro-immune crosstalk in breast cancer brain metastases

Journal for ImmunoTherapy of Cancer | April 2, 2026 | Zou, Y., Wu, J., Yuan, Z., He, X., Tang, H.

<p>Breast cancer brain metastasis (BCBrM) remains one of the most lethal manifestations of breast cancer. Its response to immunotherapy is severely limited by the blood-brain barrier, which restricts immune cell infiltration and antigen presentation, thereby creating an immunosuppressive microenvironment. To overcome these barriers, recent studies have focused on novel immune checkpoints, including the Lymphocyte-Activated Gene 3–Galectin 3 (LAG3–LGALS3) and T-Cell…

Topics: breast-cancer, lung-cancer, brain-cancer, immunotherapy, research

Read the full article at Journal for ImmunoTherapy of Cancer