Background <p>We investigated the hypothesis that transforming growth factor β induced (TGFBI), an extracellular matrix protein secreted in the microenvironment of several tumors, can act as a secreted immune checkpoint (sIC) that contributes to the suppression of human antitumor T cell responses.</p> Methods and results <p>Serum TGFBI concentrations, measured by ELISA, were significantly higher in patients with colorectal cancer (CRC)…
Transforming growth factor {beta} induced as a novel secreted immune checkpoint counterinhibiting human tumor-associated T cells
Journal for ImmunoTherapy of Cancer | | Rosado, M. M., Timperi, E., Melaiu, O., Vitale, S., Bachy, S., Grimaldi, A., Corrado, M., Mancini, V., Leonti, G., Conti, F., Cammarata, I., Celardo, I., Kucykowicz, S., Aidoo-Micah, G., Gragera, P., Accapezzato, D., Del Ben, M., DOria, V., De Stefanis, C., Forcina, L., Frattaroli, F., Picchetto, A., Chiaretti, M., DAmbrosio, G., Giannini, G., Belardinilli, F., Scarinci, A., Grazi, G. L., Musaro, A., Maini, M. K., Fiori, M. E., Fruci, D., Hennino, A., Barnaba, V.
Topics: colorectal-cancer, immunotherapy, research
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