Background <p>Insufficient T-cell infiltration limits the effectiveness of immunotherapy in sarcoma, yet the tumor-intrinsic mechanisms that govern immune exclusion remain poorly defined.</p> Methods <p>By integrating patient-derived ex vivo sarcoma spheroids with autologous expanded tumor-infiltrating lymphocytes and an in vivo metastatic osteosarcoma model, antitumor immune regulation by histone modifications was examined.</p> Results <p>Histone H3 lysine 27 acetylation (H3K27ac) was identified as…
Epigenetic remodeling in sarcoma promotes T-cell infiltration via modulation of the Hippo pathway
Journal for ImmunoTherapy of Cancer | | Cruz De los Santos, M., Chen, Y., Gonzalez De Zarate, A., Sorteberg, A., Zhao, H., Vazquez-Cabrera, G., Bigdeli, N., Kolbeinsdottir, S., Mannion, A., Baldran-Groves, L., Neo, S. Y., Wickström, S. L., Melief, J., Holmgren, L., Herold, N., Haglund de Flon, F., Lundqvist, A.
Topics: sarcoma, immunotherapy, research
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