Background <p>Pancreatic ductal adenocarcinoma (PDAC) is characterized by a profoundly immunosuppressive tumor microenvironment, which features a dense desmoplastic stroma enriched with cancer-associated fibroblasts (CAFs) that collectively impede the efficacy of immunotherapies. Although oncolytic viruses (OVs) have demonstrated promising potential in eliciting antitumor immunity, the mechanisms by which stromal components modulate OV efficacy remain poorly understood.</p> Methods <p>To investigate the interplay…
Oncolytic virus-induced IL-1{beta}+ monocyte-IL-6+ CAF axis suppresses dendritic cell-mediated antitumor immunity in pancreatic cancer
Journal for ImmunoTherapy of Cancer | | Li, F., Chen, J., Li, Y., Wang, W., Yang, Y., Wang, J., Han, M., Wang, H., Zhou, F., Ma, W., Wang, Y., Zhang, Z., Yu, J., Zhao, Z., Deng, L., Liu, S., Wan, Y., Zhao, Z., Xu, S., Li, J., Cao, Y., Zhang, H.
Topics: pancreatic-cancer, cervical-cancer, new-technology, research
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