Background <p>The translational study of chimeric antigen receptor (CAR) T-cell function, persistence, immunophenotype, and spatial localization after infusion is crucial for understanding factors that influence clinical outcomes. However, research has been limited by a lack of optimized tools to reliably detect CAR-engineered cells. To address this, we developed a novel platform to generate monoclonal antibodies (mAbs) targeting a linker peptide…
Novel antibodies for identification, selection, and manipulation of T cells expressing Whitlow linker-containing CARs
Journal for ImmunoTherapy of Cancer | | Kimble, E. L., Wright, J. H., Torkelson, A., Kirchmeier, D. R., Braathen, K., Ruff, R. O., Shimp, K. R., Seaton, B. W., Gauthier, J., Kolokythas, O., Boiani, N. E., Jellyman, D., Yeung, C. C., Tam, E., Price, J. P., Hirayama, A., Turtle, C. J.
Topics: research
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