Background <p>Only a subset of polymerase epsilon (<i>POLE</i>) mutations is associated with hypermutant phenotype; we hypothesized that only loss-of-proofreading (LOP) <i>POLE</i> mutations are associated with favorable immunotherapy response.</p> Methods <p>This retrospective cohort study included a pan-cancer cohort of 69,223 patients from cBioPortal and a cohort of patients with 41 <i>POLE</i> mutant metastatic colorectal (CRC) treated with immunotherapy at the MD…
Prognosis and treatment response stratification according to loss of proofreading (LOP) POLE variants
Journal for ImmunoTherapy of Cancer | | Maddalena, G., Zeineddine, F. A., Chowdhury, S., Zeineddine, M. A., Yousef, A. M., Bergamo, F., Lonardi, S., Yap, T. A., White, M. G., Overman, M. J., Kopetz, S., Shen, J. P.
Topics: colorectal-cancer, immunotherapy, research
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