Patient-reported outcomes (PROs) are increasingly recognised for their role in assessing tolerability in dose-finding oncology trials (DFOTs). However, analysis and reporting of PRO data within DFOTs are often unclear and inconsistent. OPTIMISE-AR (Incorporating Patient-Reported Outcomes in Dose-Finding Trials–Analysis Recommendations) establishes a practical toolkit supporting the statistical analysis, visualisation, and reporting of PRO data within DFOT publications. International, multidisciplinary, cross-sector statistical…
[Policy Review] A practical toolkit with recommendations for analysing and visualising patient-reported outcomes in early phase dose-finding oncology trials (OPTIMISE-AR)
The Lancet Oncology | | Emily Alger, Antoine Regnault, Amylou C Dueck, Madeline Pe, Michael J Grayling, Melanie J Calvert, Aaron R Hansen, Olga Kholmanskikh, Julia Lai-Kwon, J Jack Lee, Anna Minchom, Yu Qiao, Khadija Rerhou Rantell, Jessica Roydhouse, Claire Snyder, Stefan N Symeonides, Nolan A Wages, Roger Wilson, Christina Yap
Topics: oncology