Targeting shared neoantigens in solid tumours

<p>Nature Reviews Cancer, Published online: 30 March 2026; <a href="https://www.nature.com/articles/s41568-026-00925-z">doi:10.1038/s41568-026-00925-z</a></p>In this Journal Club, Terrazas and Peón discuss a study that identifies a recurrent CTNNB1 mutation that generates shared neoantigens amenable to engineered T cell receptor (TCR)-T cell recognition. The work demonstrates potent antitumour activity across models and highlights the potential of targeting public mutations to broaden TCR-T cell immunotherapy for…