Background <p>Chimeric antigen receptor T-cell (CAR-T) therapy represents a promising frontier in oncology, but its application to high-grade gliomas (HGG) is challenged by the blood-brain barrier, limited efficacy, and significant toxicities associated with systemic administration. Locoregional delivery has the potential to address these shortcomings. This systematic review evaluates the safety and efficacy of locoregional vs systemic CAR-T cell delivery for…
Locoregional delivery of CAR T cells in high-grade gliomas: a systematic analysis of safety, efficacy, and emerging biomarkers of response
Journal for ImmunoTherapy of Cancer | | Ramsoomair, C. K., Daftari, M., Benchouia, R., Estevez-Ordonez, D., Aka, A., Himic, V., Aramburu-Berckemeyer, M., Kreatsoulas, D., Govindarajan, V., Chandar, J. S., Ivan, M. E., Komotar, R. J., Shah, A.
Topics: blood-cancer, brain-cancer, immunotherapy, targeted-therapy, research
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