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Pharmacologic targeting of the dopamine D2 receptor impacts the efficacy of immune checkpoint blockade in melanoma

Journal for ImmunoTherapy of Cancer | March 29, 2026 | Gregory, M., Hackett, J. B., Hughes, S., Muniz, M. C., Ayoub, S., Boerner, A., Alrabaa, H., Taylor, L., Rivera, B., Holland, H., Dyson, G., Daveluy, S., Gibson, H.

Background <p>Immune checkpoint inhibitors (ICIs) have been successful in treating advanced melanoma, yet, the 10-year melanoma-specific survival is only 52%. Our prior work using genetic linkage analysis revealed that the murine prolactin (PRL) locus associates with ICI response in C57BL/6 (B6)-syngeneic B16F0 melanoma. This was validated in F1 crosses of B6 with Collaborative Cross mice selected as potential non-responders or…

Topics: skin-cancer, immunotherapy, research

Read the full article at Journal for ImmunoTherapy of Cancer