Background <p>The liver’s inherently immunosuppressive microenvironment presents a major barrier to effective immunotherapy for hepatocellular carcinoma (HCC). Although interleukin-10 (IL-10) has demonstrated antitumor activity in several cancer models, its therapeutic potential in HCC remains unclear. Here, we investigated whether liver-directed delivery of IL-10 using an adeno-associated virus vector (AAV-IL-10) could enhance antitumor immunity in HCC.</p> Methods <p>Syngeneic orthotopic and intrahepatic…
Liver-directed AAV-IL-10 therapy enhances CD8+ T cell-mediated immunity against hepatocellular carcinoma
Journal for ImmunoTherapy of Cancer | | Lin, C.-I., Chiu, Y.-W., Yen, M.-S., Wang, Y.-W., Wu, Y.-H., Chuang, Y.-H.
Topics: liver-cancer, cervical-cancer, immunotherapy, research
Read the full article at Journal for ImmunoTherapy of Cancer