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Functional m<sup>6</sup>A site detection by FOCAS

Nature Reviews Cancer | March 25, 2026 | Yifan Zhang

<p>Nature Reviews Cancer, Published online: 25 March 2026; <a href="https://www.nature.com/articles/s41568-026-00926-y">doi:10.1038/s41568-026-00926-y</a></p>In this Tools of the Trade article, Yifan Zhang describes the development and use of FOCAS, a platform for site-specific, transcriptome-wide mapping of functional m6A RNA modifications, revealing widespread intra-transcript functional diversity and uncovering epitranscriptomic and epigenomic interactions that shape cancer cell fitness.

Topics: research

Read the full article at Nature Reviews Cancer