Background <p>Identifying effective therapeutic drugs in the intricate tumor microenvironment (TME) is challenging, further complicated by the lack of a systematic framework for analyzing TME perturbations in response to therapeutic interventions.</p> Methods <p>To address this, we established the single-cell RNA sequencing repository of immunomodulatory drugs resource and used the L1000 platform for unbiased screening of 739 immune-modulating compounds across various…
Single-cell-based identification of drug synergy with immunotherapy via tumor microenvironment remodeling
Journal for ImmunoTherapy of Cancer | | Wang, Z., Hu, J., Liu, K., Xu, J., Li, J., Liu, Y., Ma, Q., Dong, Y., Zhu, Y., Zhang, K., Wang, D., Wang, X., Wang, S., Pan, J., Jiang, S., Wu, J., Jiang, W., Zhang, L., Dang, Y.
Topics: blood-cancer, cervical-cancer, immunotherapy, prevention, new-technology
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