Purpose: Reliable prediction of invasive progression remains an unmet need in ductal carcinoma in situ (DCIS). Conventional histologic grading provides limited prognostic value. Building on mechanistic evidence that cell crowding in confined ducts engages a TRPV4-dependent mechanotransduction program, we evaluated plasma-membrane TRPV4 (PM-TRPV4) localization as a mechanosensitive, patient-level prognostic biomarker for progression to invasive ductal carcinoma (IDC). Experimental Design: In…
Plasma Membrane TRPV4 Relocalization as a Mechanosensitive Prognostic Biomarker in Ductal Carcinoma In Situ
medRxiv Oncology | | Chan, C., Arbzadeh, E., Samankan, S., Latham, P., Schwartz, A., Du, R., Chung, I.
Topics: breast-cancer, cervical-cancer, targeted-therapy, research