Proteins that drive or support human disease phenotypes are attractive molecular targets for precision therapy, yet most are nominated by knockout studies and then targeted with drugs that inhibit core catalytic pockets. These strategies cannot resolve which residues are essential, whether non-catalytic sites offer better selectivity or potency, or identify on-target resistance mechanisms. We introduce a framework that integrates precision…
A functional map of CDK-drug interactions at single amino acid resolution
bioRxiv Cancer Biology | | Gould, S. I., Acosta, J., Bielo, L. B., Jaboldinov, A., Johnson, G. A., Contreras, M. E., Wuest, A. N., Bremont, E., Toure, M. A., Xiang, Y., Kozicka, Z., Hemann, M. T., Koehler, A. N., Chandarlapaty, S., Rivera, F. J. S.
Topics: skin-cancer, research