The spontaneous regression of cancer lesions demonstrates the potential of immune surveillance; yet, these transient events have remained inaccessible to systematic study. Using longitudinal intravital microscopy in a carcinogen-induced model of head and neck cancer, we tracked premalignant lesions within the same animals for 24 weeks at single-cell resolution. This approach revealed three trajectories: progression, stability, or regression, and enabled…
Longitudinal Imaging of the Premalignant Tumor Microenvironment Reveals Transient Myeloid States Predictive of Tumor Fate
bioRxiv Cancer Biology | | Madsen, T. D., Chen, D., Maria, H., Hammoudeh, S., Heydecker, M., Chen, E., Abu-Elnaj, S., Kedei, N., Wang, W., Weigert, R.
Topics: cervical-cancer, head-neck-cancer, prevention, new-technology, research