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Lamin B1 Safeguards the B Cell Genome and Shapes Lymphoma Outcome

bioRxiv Cancer Biology | November 7, 2025 | Filipsky, F., Chapman, K. B., Bloehdorn, J., Wang, J., Gribben, J., Hausmann, M., Cremer, C., Braun, A., Crespi Sallan, M., Klymenko, T.

Lamin B1 is a structural component of the nuclear lamina that participates in diverse cellular processes, including genome regulation and cellular senescence. During adaptive immune responses, B lymphocytes in germinal centres (GCs) undergo clonal expansion and programmed DNA damage at immunoglobulin loci, while simultaneously downregulating Lamin B1. Likewise, Lamin B1 downregulation has been observed in GC-derived lymphomas and myeloid malignancies,…

Topics: blood-cancer

Read the full article at bioRxiv Cancer Biology