Background <p>Immunotherapy has transformed cancer treatment, highlighting the importance of effective antitumor immunity to fight cancer. However, its success in pediatric cancer remains limited, underscoring the urgent need to identify new immunotherapeutic targets. In this study, we explored the clinical relevance of B cells and tertiary lymphoid structures (TLS) in neuroblastoma (NB), a pediatric tumor with a heterogeneous immune landscape.</p>…
Mapping B cells and the immune landscape of tertiary lymphoid structures reveals their clinical impact in neuroblastoma
Journal for ImmunoTherapy of Cancer | | Melaiu, O., Chierici, M., Gragera, P., Lazzaro, N., Petrilli, L. L., Wienke, J., Bergsma, F. J., Verhoeven, B. M., De Stefanis, C., DOria, V., Benedetti, M. C., Barillari, G., Alaggio, R., De Ioris, M. A., Vinci, M., Baryawno, N., Carsetti, R., Jurman, G., Molenaar, J. J., Locatelli, F., Fruci, D.
Topics: pediatric-cancer, immunotherapy, research
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