Background <p>Oncolytic virus M1 (OVM), a naturally occurring alphavirus, has demonstrated potent antitumor activity in various solid tumor models by inducing immunogenic cell death and activating CD8<sup>+</sup> T cells. However, its in vivo efficacy varies widely, and resistance mechanisms remain poorly understood. Tumor-associated macrophages (TAMs), key immunosuppressive cells within the tumor microenvironment, may limit OVM therapeutic potential.</p> Methods <p>We investigated…
TAMs-mediated resistance to oncolytic virus M1 in solid tumors
Journal for ImmunoTherapy of Cancer | | Liang, X., Li, J., Chen, J., Chen, C., Li, H., Yan, C., Guo, C., Han, Y., Liu, W., Sai, K., Lin, Y., Yan, G., Zhu, W., Liu, Y.
Topics: blood-cancer, cervical-cancer, new-technology, research
Read the full article at Journal for ImmunoTherapy of Cancer