Background <p>The efficacy of immunotherapy is often hindered by the suppression of immune responses via the tumor microenvironment (TME). The presence of cancer cells forces other proximal non-cancerous cells to support tumor growth and persistence. A clear example of this cancerous-to-non-cancerous communication is represented by the accumulation of myeloid-derived suppressor cells (MDSCs) within the TME. Several studies have convergently shown…
Effect of extracellular vesicles in remodeling the tumor microenvironment by DNMT1 downregulation for enhanced cancer immunotherapy
Journal for ImmunoTherapy of Cancer | | Russo, S., Giannoula, Y., Feola, S., Cerioni, J., Hamdan, F., Chiaro, J., Ha Dang, A. T., Bottega, P., Feodoroff, M., Fusciello, M., Stigzelius, V., DAmico, C., Caiazza, C., Antignani, G., DAlessio, F., Sakalauskaite, M., Petryk, J., Bell, J., Ilkow, C., Grönholm, M., Cerullo, V.
Topics: immunotherapy, new-technology
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