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One, two, many: how many cells start a tumour?

Nature Reviews Cancer | November 17, 2025 | Carla Daniela Robles-Espinoza

<p>Nature Reviews Cancer, Published online: 14 November 2025; <a href="https://www.nature.com/articles/s41568-025-00895-8">doi:10.1038/s41568-025-00895-8</a></p>In this Journal Club, Basurto-Lozada and Robles-Espinoza discuss a study that challenges the prevailing view of a monoclonal origin of cancer by showing that early lesions in mouse models of colorectal cancer are polyclonal.

Topics: colorectal-cancer, blood-cancer, research

Read the full article at Nature Reviews Cancer