Cellular architecture depends on keratin intermediate filament as a fundamental component, which offers essential mechanical support to fight environmental stresses. Our previous research demonstrated that keratin fusion variants increase tumor aggressiveness through enhanced cancer stemness in oral squamous cell carcinoma. The proper functioning of keratins plays an essential role in maintaining cell structure while determining cell fate. The present study…
Cytoskeleton remodeling caused by keratin dysregulation triggers tumor aggressiveness via promoting genomic instability and cellular adaption
bioRxiv Cancer Biology | | Chuang, H.-H., Kuo, B. Y.-T., Sriramadasu, K., Lai, M.-T., Lin, L. Y.-T., Boominathan, P. K., Hwang, T., Chen, Y.-C., Chen, C.-M., Chang, C. Y.-Y., Sheu, J. J.-C.
Topics: cervical-cancer, research