AGPAT3 reshapes tumor cell vulnerability to IFN{gamma}-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling

Background <p>Ferroptosis plays a critical role in immune regulation and tumor microenvironment remodeling. However, its therapeutic potential in enhancing immune checkpoint inhibitor (ICI) efficacy remains incompletely understood and warrants further investigation.</p> Methods <p>To investigate the potential of ferroptosis in improving ICI response, we constructed a machine learning-based predictive model using ferroptosis-related genes and analyzed large-scale single-cell RNA sequencing datasets. Mechanistic…