Background <p>Peritoneal metastasis (PM) is one of the most challenging clinical problems in gastric cancer (GC), largely due to its high recurrence rate and poor response to current therapies. Increasing evidence indicates that remodeling of the extracellular matrix (ECM) plays an important role in therapeutic failure. However, how specific stromal–immune interactions contribute to PM heterogeneity and immunotherapy resistance remains unclear.…
Hyaluronic acid-CD44 signaling defines therapeutic resistance and immunosuppressive microenvironment in peritoneal metastasis of gastric cancer
Journal for ImmunoTherapy of Cancer | | Zhao, J., Ji, C., Sun, J., Tian, C., Cai, T., Wang, Z., Sun, Z., Li, B., Ma, G., Liu, D., Yamamoto, M., Tsukamoto, T., Nomura, S., Sun, L., Sun, Y., Huang, L., Ruan, Y., Li, H., Wang, X.
Topics: blood-cancer, stomach-cancer, immunotherapy, research
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