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Integrative transcriptomic analysis identifies miR-642a-5p as a regulator of POFUT1 expression in colon cancer

bioRxiv Cancer Biology | November 7, 2025 | Mazour, O., Ababou, M., Badaoui, B., Germot, A.

Background: Colorectal cancer (CRC) is one of the most common and deadly cancers worldwide, underscoring the urgent need for novel biomarkers and therapeutic targets. Protein-O-fucosyltransferase 1 (POFUT1) is increasingly recognized as an oncogenic driver in CRC, but the upstream regulatory mechanisms responsible for its overexpression remain poorly understood. Objective: We aimed to identify a reproducible miRNA signature potentially regulating POFUT1…

Topics: colorectal-cancer, blood-cancer, targeted-therapy, research

Read the full article at bioRxiv Cancer Biology