TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a malignant soft tissue sarcoma with a skeletal muscle phenotype, accounting for approximately 50% of all pediatric soft tissue sarcomas and 8% of all childhood cancers. Although RMS cells express myogenic regulatory factors, they fail to undergo terminal differentiation into mature muscle cells. Transforming growth factor {beta}-activated kinase 1 (TAK1) is a major signaling protein that activates…