Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with an unmet medical need. therapeutic elimination of cancer associated fibroblasts (CAFs), key drivers of tumor aggressiveness, has been the focus of recent studies. However, the inherent heterogeneity and plasticity of CAFs have hampered the development of CAF-targeted therapies. Clemastine, an FDA-approved cationic amphiphilic drug, is known to elicit cytotoxic lysosomal membrane…
Therapeutic Eradication of Cancer-associated Fibroblasts Inhibits in vivo progression of Pancreatic Cancer
bioRxiv Cancer Biology | | Roos-Mattila, M., Mustonen, H., Vaha-Koskela, M., Boyd, S., Vainionpaa, S., Hwang, R. F., Puolakkainen, P., Le Joncour, V., Laakkonen, P., Seppanen, H.
Topics: pancreatic-cancer, cervical-cancer, chemotherapy, research